2. SOUNDBITE (English) Dr. James Allison, Winner of the Nobel Prize in Medicine:
"I want to start by saying I'm still in sort of a state of shock and this is also sinking in so I'll try to, you know, might make some sense while I'm talking here."
3. SOUNDBITE (English) Dr. James Allison, Winner of the Nobel Prize in Medicine:
"I guess the reason I'm really thrilled about this is I'm a basic scientist. I did not get in to these studies to try to cure cancer. I got into it because I wanted to know how T cells worked. And once we showed that this molecule CTLA-4 was the first cell-intrinsic negative regulators with immune responses that immediately occurred to me and some of the people my lab that maybe we can use this to unleash the immune system to attack cancer cells. And so, I'm lucky enough that as a basic scientist to see my work actually end up, 20 years later actually, really, really helping patients."
4. SOUNDBITE (English) Dr. James Allison, Winner of the Nobel Prize in Medicine:
"It was always in the back of my mind, it wasn't a reason I was doing the work, but whenever I could take a rest you know from thinking about the problem and look at that data and say, what does this tell me that I could use to treat cancer. And I was one of those moments where we figured out that that CTLA-4 was the brakes on the immune system, I said, well let's just disable the brakes and see if that that will allow the immune system to attack cancer, and it did."