LEAD IN:

For decades Britain's discontent over its European Union (EU) membership has simmered on, but then came the June referendum.

Nationalism surfaced and Britain's voted to leave the EU.

Brexit as it became known sent shockwaves through money markets and governments around the world.

STORY-LINE:

In the weeks running up to referendum judgement day, the British were busy with a little soul searching.

Mulling over their shared history, the country's pride in their democracy and heritage.

It was a year when Queen Elizabeth celebrated being the longest reigning UK monarch and the country celebrated her ninetieth birthday.

The pomp and ceremony from her recent jubilee were still a source of pride and were reminiscent of the heydays when London style was considered to be world leading.

In the 1960's British fashion and British pop were riding high.

That sense of being at the vanguard of style has continued, according to Robert Johnston the Fashion Director of GQ Magazine: "You also think street scene, you think east London, you think hipsters, you think the most vibrant street fashion possibly in the world."

Author Iain Aitch explained how a variety of heritages were now mixed up, making Britishness a more complex idea to communicate: "Everyone might say a Sunday roast or fish and chips, that's a quintessentially British meal, but then suddenly everyone says it's chicken tikka masala."

But it wasn't this hipster, Brick Lane art and curry house side of Britain that won the vote.

The referendum on June 23rd was to signal the start of a long debate.

Britons for the first time had to absorb what being outside of the EU looked like.

Britain joined what was then called the European Economic Community in January 1973.

This was ratified by a referendum in 1975 with a resounding 67% majority.

By the seventies, Britain was beset by strikes and disgruntled union workers.

Traditional industries such as manufacturing and coal were in decline in the mid seventies.

Unemployment exceeded one million for the first time in March 1975. By the August that figure had increased to 1.25 million.

Some 83,000 immigrants were living in the UK by 1975, mostly from the Commonwealth.

According to Migration Watch UK for the year ending December 2015, net migration to the UK was 333,000.

And the lady had yet to turn. Margaret Thatcher MP (then leader of the opposition) campaigned to stay in the European Economic Community.

Later as prime minister between 1979 and 1990, Thatcher was known for her tough line with Brussels, especially during negotiations for the Maastrict Treaty in 1992.

The city of Maastrict is the home of the treaty which created the EU.

As summer arrived, businesses, leading universities and research establishments were beginning to assess the impact of Brexit.

For science and medicine, concerns were two fold.

Britain had attracted thousands of top researchers as well as billions of Euros in grants.

They went into research like this at Kings College London.

This project is a multidisciplinary look at the potential causes and effects of autism. It's a long term project which is linked to other studies across Europe.

Doctors and scientists aren't worried about losing cash in the short term, but falling behind in the knowledge race in the long term, especially as Britain has sought to place itself as a central base for the new industrial technologies.

The other fear is losing the brains which have been drawn to British research, people who now fear they will need to move to other institutions to keep up with the cash and the research.

Lead scientist at King's College Professor Declan Murphy warned: "Big questions need big populations to come up with the right answers, and we simply cannot deliver the amount of patients for the amount of science from one centre from one country."

The EU's Horizon 2020 budget is 80-billion Euro which funds medicine and science research across Europe.

Britain's split from the EU will leave a funding gap as well as a brain drain, according to Murphy. He argues it will be the children with autism like Van Velzen who will lose out.

As an island nation, boat building and sales have been important to the UK.

The industry fears rough waters may be ahead for Britain's luxury yacht industry, but right now it's riding on a wave caused by the plunge in the pound's value.

Phil Popham, the CEO of Sunseeker International was cautious: "We've benefited because of the weakness of the pound, but its all about business confidence."

Others like Russell Currie, the Managing Director of Fairline Yachts, says he already had cause to worry: "We've had an overnight decrease in the price of our boats in areas such as the European market."

British Marine's chief executive Howard Pridding tried to show more confidence in the course ahead: "Obviously, industry and business need stability and the time it will take to exit from the European Union will be problematic."

An estimated 1.2 million Britons live in other EU countries, mostly France, Portugal and Spain according to Britain's House of Commons library.

But that's a conservative figure because many expats don't bother registering with their embassies or the local authorities.

At Mijas on Spain's Costa del Sol, many Brits don't want to return to Blighty.

Used to the sun, sea and cafe society, some British residents are so concerned that their lives on the Costas are threatened, that after many years they're finally learning to speak Spanish.

According to Mijas' Mayor Juan Carlos Maldonado: "When the results of the Brexit (referendum) were known, a big uncertainty was created."

Local traders are also keen to keep the British on the Costa.

Many are retired and spend their pensions here.

Bar owner Sergio Morales says: "Most of our clients here, around 80% of them, are British."

A cloud of uncertainty still hangs over British expats in Spain and elsewhere in Europe.

And it's possible a string of similar nationality schools for expats may spring up.

Not everyone was bemoaning the onset of Brexit.

The art and antique market experienced a mini boom according to London dealers at this winter fair.

The weak pound against the dollar and Euro has seen American collectors in particular start to snap up bargains with savings of beween 25 and 30 per cent compared with six months ago.

Art dealers are reporting a similar trend.

They say investors see the arts market as a safe refuge in uncertain times.

As Christmas approaches the toy industry is bracing itself and Santa is wondering whether he'll have much to be jolly about.

It's the time of year when manufacturers and retailers count on making their biggest cash bonus of the year.

According to industry analyst Frederique Tutt: "Since the Brexit vote the toy market has been faring really well with an increase of three percent."

That's because toy retailers buy stock almost a year in advance and can keep prices stable, but the toy dealers here admit next year the stockings left out for Father Chrismas may have shrunk considerably.

There's nothing as Christmassy as a Christmas tree, but in Denmark the outlook for tree producers isn't quite so evergreen.

According to the Danish Christmas Tree Association, the small Scandinavian country grows around 11.5 million trees a year.

About 9.5 million of those are exported.

But these are challenging times and currency fluctuations are having an effect on trade.

Speaking about his members, Claus Jerram Christensen of the Danish Christmas Tree Association says: "They have experienced that the low exchange rate for the sterling pound makes it more difficult to achieve the same prices."

The true impact of Brexit on Britain and Europe as a whole is still to an extent unknown.

The UK government had announced it was to trigger Article 50 next March to start negotiations to leave EU.

But since then, Brexit has twice been contested in the High Court.

One ruling has already stated Britain's law makers should be allowed a vote in Parliament beforehand.

Breaking up, it seems, really is hard to do.

AP Television

London, UK - 22 February 2016

1. Wide of UK Houses of Parliament as London bus passes

2. Close of clock face at the top of Elizabeth Tower, which houses Big Ben

AP Television

London, UK - 16 June 2016

3. Wide of Big Ben as seen from Buckingham Palace

4. Wide of Buckingham Palace

POOL

London, UK - 3 June 2012

5. Queen Elizabeth II with Prince Philip (centre), Charles (left) and Camilla (right) on royal barge during Diamond Jubilee celebrations

6. Mid of Duke and Duchess of Cambridge and Prince Harry on royal barge

7. Pull out of royal barge sailing down River Thames during Diamond Jubilee celebrations

AP Television

London, UK - 11 June, 2016

8. Mid of Queen Elizabeth II in carriage during the Trooping of the Colour for her 90th birthday celebrations

9. Wide of Guardsmen in ceremonial marching during the celebrations

AP Television

London, UK - 1960s

++BLACK AND WHITE FOOTAGE / MUTE++

++4:3++

10. Close tilt down of man putting shirt in carrier bag

11. Wide of man by scooters

UNIVERSAL ARCHIVES

London, UK - 31 October 1963

++BLACK AND WHITE FOOTAGE / MUTE++

++4:3++

12. Various of Beatles getting off plane in London

AP Television

London, UK - 7 June 2016

++16:9++

13. SOUNDBITE (English) Robert Johnston, Fashion Director, GQ Magazine UK

"You also think street scene, you think east London, you think hipsters, you think the most vibrant street fashion possibly in the world."

AP Television

London, UK - 3 July 2012

14. Punk and goth street fashion in Camden

AP Television

London, UK - 16 June, 2016

15. Hipster in Brick Lane cafe

16. Pull focus of street sign reading: (English) "Brick Lane E1"

17. Various of curry houses on Brick Lane

AP Television

Margate, UK - 8 June 2016

18. Various of Margate beach and people relaxing in sunshine

19. SOUNDBITE (English) Iain Aitch, Author:

"Everyone might say a Sunday roast or fish and chips, that's a quintessentially British meal, but then suddenly everyone says it's chicken tikka masala."

20. Various of takeaway fish and chips being served

AP Television

London, United Kingdom, April 30, 1973 (MUTE)

++4:3++

21. Red buses on a London street

AP Television

London, United Kingdom, September 24, 1973 (MUTE)

++4:3++

22. Tilt down of Ford workers walking out of various plants

23. Wide of Ford cars on a train

24. Various men take part in industrial action at Ford plant

AP Television

United Kingdom, February 10, 1974 - no exact location available

++4:3++

25. Various of non functioning coal mines during national coal strike

AP Television

London, United Kingdom, June 3, 1975 (MUTE)

++4:3++

26. Mid of Margaret Thatcher wearing a flags-of-Europe sweater, flanked by women also wearing pro-Europe sweaters

AP Television

Maastricht, Netherlands - 7 June 2016

++16:9++

27. Clocktower of Maastricht town hall with EU, Limburg and Maastricht flags

28. Wide of streets in the town

AP Television

London, UK - 7 July 2016

29. Various of autistic teenager Rens Van Velzen completing other puzzles with black and yellow blocks against the clock

30. Close tilt down of the psychologist on the autism study at Kings College London timing Rens Van Velzen during test

31. Close of Van Velzen

32. SOUNDBITE (English) Professor Declan Murphy lead scientist, EU Aims study on autism, Kings College London:

"Big questions need big populations to come up with the right answers, and we simply cannot deliver the amount of patients for the amount of science from one centre or from one country."

33. Various of Van Velzen being tested in eye tracking unit at Kings College London

AP Television

Southampton, UK - 16 September 2016

34. Wide of Southampton Boat Show 2016, cruise ship in background

35. Tilt down to pontoon, boats and visitors

36. Close of 'Sunseeker' flag

37. Various of Sunseeker 95 Yacht exterior

38. SOUNDBITE (English) Phil Popham, CEO of Sunseeker International:

"We've benefited because of the weakness of the pound, but its all about business confidence."

39. Various of Fairline yacht

40. SOUNDBITE (English) Russell Currie, Managing Director of Fairline Yachts:

"We've had an overnight decrease in the price of our boats in areas such as the European market

41. Zoom out from cruise ship docked near boat show

42. SOUNDBITE (English) Howard Pridding, Chief Executive of British Marine:

"Industry and business need stability and the time it will take to exit from the European Union will be problematic"

AP Television

Mijas, Malaga - October 6, 2016

43. Wide of coastal area of Mijas

44. Pan of typical apartments in the area and people walking by the sea side

45. Various of British pensioners taking Spanish classes in the Parnell School

46. Various of Juan Mayor Carlos Maldonado in his office

47. SOUNDBITE (Spanish) Juan Carlos Maldonado, Mayor of Mijas:

"When the results of the Brexit (referendum) were known, a big uncertainty was created."

48. Various of family walking near beach

49. Pan from people walking up steps from the beach to the owner of Royal Beach cafe talking

50. SOUNDBITE (Spanish) Sergio Morales, co-owner of Royal Beach bar in Mijas:

"Most of our clients here, around 80% of them, are British."

AP Television

London, UK - 1 November 2016

51. Pull focus of bronze Japanese archer

52. Mid of men admiring antique chandelier

53. Art dealer Tanya Baxter showing painting to visitor

54. Close tilt down of painting 'Paper Bride in Waiting' by Zeng Chuanxing (price £120,000/ USD 147,000)

55. Wide of antique clock stand

AP Television

London, UK - 9 November 2016

56. Mid of Tiana Wilson with Santa who is holding a Hatchimal waiting for the toy to hatch

57. Wide of girl playing with toy on chair

58. Mid zoom in to boys playing with Bluetooth Furbys

59. Low mid view of caterpillar going past boys and Furbys

60. SOUNDBITE (English) Frederique Tutt, toy industry analyst, NPD:

"Since the Brexit vote the toy market has been faring really well with an increase of three percent."

AP Television

Lundby, Denmark - 22 November 2016

61. Mid tilt up of Christmas tree plantation

62. Wide of plantation through tops of trees

AP Television

Copenhagen, Denmark - 21 November 2016

63. SOUNDBITE (English) Claus Jerram Christensen, Managing Director of the Danish Christmas Tree Association:

"The low exchange rate for the sterling pound makes it more difficult to achieve the same prices."

64. Mid of large container truck filled with trees pulling out of yard stacked with trees

65. Pan across field of Christmas tree saplings for 2018 and beyond

WORLD BREXIT REVIEW

SOURCE: AP HORIZONS, LIFESTYLE, HEALTH AND TECHNOLOGY / POOL

RESTRICTIONS: HORIZONS CLIENTS AND AP LIFESTYLE, HEALTH AND TECHNOLOGY CLIENTS ONLY

LENGTH: 6.44

SHOTLIST:

AP Television

London, UK - 22 February 2016

1. Wide of UK Houses of Parliament as London bus passes

2. Close of clock face at the top of Elizabeth Tower, which houses Big Ben

AP Television

London, UK - 16 June 2016

3. Wide of Big Ben as seen from Buckingham Palace

4. Wide of Buckingham Palace

POOL

London, UK - 3 June 2012

5. Queen Elizabeth II with Prince Philip (centre), Charles (left) and Camilla (right) on royal barge during Diamond Jubilee celebrations

6. Mid of Duke and Duchess of Cambridge and Prince Harry on royal barge

7. Pull out of royal barge sailing down River Thames during Diamond Jubilee celebrations

AP Television

London, UK - 11 June, 2016

8. Mid of Queen Elizabeth II in carriage during the Trooping of the Colour for her 90th birthday celebrations

9. Wide of Guardsmen in ceremonial marching during the celebrations

AP Television

London, UK - 1960s

++BLACK AND WHITE FOOTAGE / MUTE++

++4:3++

10. Close tilt down of man putting shirt in carrier bag

11. Wide of man by scooters

UNIVERSAL ARCHIVES

London, UK - 31 October 1963

++BLACK AND WHITE FOOTAGE / MUTE++

++4:3++

12. Various of Beatles getting off plane in London

AP Television

London, UK - 7 June 2016

++16:9++

13. SOUNDBITE (English) Robert Johnston, Fashion Director, GQ Magazine UK

"You also think street scene, you think east London, you think hipsters, you think the most vibrant street fashion possibly in the world."

AP Television

London, UK - 3 July 2012

14. Punk and goth street fashion in Camden

AP Television

London, UK - 16 June, 2016

15. Hipster in Brick Lane cafe

16. Pull focus of street sign reading: (English) "Brick Lane E1"

17. Various of curry houses on Brick Lane

AP Television

Margate, UK - 8 June 2016

18. Various of Margate beach and people relaxing in sunshine

19. SOUNDBITE (English) Iain Aitch, Author:

"Everyone might say a Sunday roast or fish and chips, that's a quintessentially British meal, but then suddenly everyone says it's chicken tikka masala."

20. Various of takeaway fish and chips being served

AP Television

London, United Kingdom, April 30, 1973 (MUTE)

++4:3++

21. Red buses on a London street

AP Television

London, United Kingdom, September 24, 1973 (MUTE)

++4:3++

22. Tilt down of Ford workers walking out of various plants

23. Wide of Ford cars on a train

24. Various men take part in industrial action at Ford plant

AP Television

United Kingdom, February 10, 1974 - no exact location available

++4:3++

25. Various of non functioning coal mines during national coal strike

AP Television

London, United Kingdom, June 3, 1975 (MUTE)

++4:3++

26. Mid of Margaret Thatcher wearing a flags-of-Europe sweater, flanked by women also wearing pro-Europe sweaters

AP Television

Maastricht, Netherlands - 7 June 2016

++16:9++

27. Clocktower of Maastricht town hall with EU, Limburg and Maastricht flags

28. Wide of streets in the town

AP Television

London, UK - 7 July 2016

29. Various of autistic teenager Rens Van Velzen completing other puzzles with black and yellow blocks against the clock

30. Close tilt down of the psychologist on the autism study at Kings College London timing Rens Van Velzen during test

31. Close of Van Velzen

32. SOUNDBITE (English) Professor Declan Murphy lead scientist, EU Aims study on autism, Kings College London:

"Big questions need big populations to come up with the right answers, and we simply cannot deliver the amount of patients for the amount of science from one centre or from one country."

33. Various of Van Velzen being tested in eye tracking unit at Kings College London

AP Television

Southampton, UK - 16 September 2016

34. Wide of Southampton Boat Show 2016, cruise ship in background

35. Tilt down to pontoon, boats and visitors

36. Close of 'Sunseeker' flag

37. Various of Sunseeker 95 Yacht exterior

38. SOUNDBITE (English) Phil Popham, CEO of Sunseeker International:

"We've benefited because of the weakness of the pound, but its all about business confidence."

39. Various of Fairline yacht

40. SOUNDBITE (English) Russell Currie, Managing Director of Fairline Yachts:

"We've had an overnight decrease in the price of our boats in areas such as the European market

41. Zoom out from cruise ship docked near boat show

42. SOUNDBITE (English) Howard Pridding, Chief Executive of British Marine:

"Industry and business need stability and the time it will take to exit from the European Union will be problematic"

AP Television

Mijas, Malaga - October 6, 2016

43. Wide of coastal area of Mijas

44. Pan of typical apartments in the area and people walking by the sea side

45. Various of British pensioners taking Spanish classes in the Parnell School

46. Various of Juan Mayor Carlos Maldonado in his office

47. SOUNDBITE (Spanish) Juan Carlos Maldonado, Mayor of Mijas:

"When the results of the Brexit (referendum) were known, a big uncertainty was created."

48. Various of family walking near beach

49. Pan from people walking up steps from the beach to the owner of Royal Beach cafe talking

50. SOUNDBITE (Spanish) Sergio Morales, co-owner of Royal Beach bar in Mijas:

"Most of our clients here, around 80% of them, are British."

AP Television

London, UK - 1 November 2016

51. Pull focus of bronze Japanese archer

52. Mid of men admiring antique chandelier

53. Art dealer Tanya Baxter showing painting to visitor

54. Close tilt down of painting 'Paper Bride in Waiting' by Zeng Chuanxing (price £120,000/ USD 147,000)

55. Wide of antique clock stand

AP Television

London, UK - 9 November 2016

56. Mid of Tiana Wilson with Santa who is holding a Hatchimal waiting for the toy to hatch

57. Wide of girl playing with toy on chair

58. Mid zoom in to boys playing with Bluetooth Furbys

59. Low mid view of caterpillar going past boys and Furbys

60. SOUNDBITE (English) Frederique Tutt, toy industry analyst, NPD:

"Since the Brexit vote the toy market has been faring really well with an increase of three percent."

AP Television

Lundby, Denmark - 22 November 2016

61. Mid tilt up of Christmas tree plantation

62. Wide of plantation through tops of trees

AP Television

Copenhagen, Denmark - 21 November 2016

63. SOUNDBITE (English) Claus Jerram Christensen, Managing Director of the Danish Christmas Tree Association:

"The low exchange rate for the sterling pound makes it more difficult to achieve the same prices."

64. Mid of large container truck filled with trees pulling out of yard stacked with trees

65. Pan across field of Christmas tree saplings for 2018 and beyond

LEADIN:

For decades Britain's discontent over its European Union (EU) membership has simmered on, but then came the June referendum.

Nationalism surfaced and Britain's voted to leave the EU.

Brexit as it became known sent shockwaves through money markets and governments around the world.

STORYLINE:

In the weeks running up to referendum judgement day, the British were busy with a little soul searching.

Mulling over their shared history, the country's pride in their democracy and heritage.

It was a year when Queen Elizabeth celebrated being the longest reigning UK monarch and the country celebrated her ninetieth birthday.

The pomp and ceremony from her recent jubilee were still a source of pride and were reminiscent of the heydays when London style was considered to be world leading.

In the 1960's British fashion and British pop were riding high.

That sense of being at the vanguard of style has continued, according to Robert Johnston the Fashion Director of GQ Magazine: "You also think street scene, you think east London, you think hipsters, you think the most vibrant street fashion possibly in the world."

Author Iain Aitch explained how a variety of heritages were now mixed up, making Britishness a more complex idea to communicate: "Everyone might say a Sunday roast or fish and chips, that's a quintessentially British meal, but then suddenly everyone says it's chicken tikka masala."

But it wasn't this hipster, Brick Lane art and curry house side of Britain that won the vote.

The referendum on June 23rd was to signal the start of a long debate.

Britons for the first time had to absorb what being outside of the EU looked like.

Britain joined what was then called the European Economic Community in January 1973.

This was ratified by a referendum in 1975 with a resounding 67% majority.

By the seventies, Britain was beset by strikes and disgruntled union workers.

Traditional industries such as manufacturing and coal were in decline in the mid seventies.

Unemployment exceeded one million for the first time in March 1975. By the August that figure had increased to 1.25 million.

Some 83,000 immigrants were living in the UK by 1975, mostly from the Commonwealth.

According to Migration Watch UK for the year ending December 2015, net migration to the UK was 333,000.

And the lady had yet to turn. Margaret Thatcher MP (then leader of the opposition) campaigned to stay in the European Economic Community.

Later as prime minister between 1979 and 1990, Thatcher was known for her tough line with Brussels, especially during negotiations for the Maastrict Treaty in 1992.

The city of Maastrict is the home of the treaty which created the EU.

As summer arrived, businesses, leading universities and research establishments were beginning to assess the impact of Brexit.

For science and medicine, concerns were two fold.

Britain had attracted thousands of top researchers as well as billions of Euros in grants.

They went into research like this at Kings College London.

This project is a multidisciplinary look at the potential causes and effects of autism. It's a long term project which is linked to other studies across Europe.

Doctors and scientists aren't worried about losing cash in the short term, but falling behind in the knowledge race in the long term, especially as Britain has sought to place itself as a central base for the new industrial technologies.

The other fear is losing the brains which have been drawn to British research, people who now fear they will need to move to other institutions to keep up with the cash and the research.

Lead scientist at King's College Professor Declan Murphy warned: "Big questions need big populations to come up with the right answers, and we simply cannot deliver the amount of patients for the amount of science from one centre from one country."

The EU's Horizon 2020 budget is 80-billion Euro which funds medicine and science research across Europe.

Britain's split from the EU will leave a funding gap as well as a brain drain, according to Murphy. He argues it will be the children with autism like Van Velzen who will lose out.

As an island nation, boat building and sales have been important to the UK.

The industry fears rough waters may be ahead for Britain's luxury yacht industry, but right now it's riding on a wave caused by the plunge in the pound's value.

Phil Popham, the CEO of Sunseeker International was cautious: "We've benefited because of the weakness of the pound, but its all about business confidence."

Others like Russell Currie, the Managing Director of Fairline Yachts, says he already had cause to worry: "We've had an overnight decrease in the price of our boats in areas such as the European market."

British Marine's chief executive Howard Pridding tried to show more confidence in the course ahead: "Obviously, industry and business need stability and the time it will take to exit from the European Union will be problematic."

An estimated 1.2 million Britons live in other EU countries, mostly France, Portugal and Spain according to Britain's House of Commons library.

But that's a conservative figure because many expats don't bother registering with their embassies or the local authorities.

At Mijas on Spain's Costa del Sol, many Brits don't want to return to Blighty.

Used to the sun, sea and cafe society, some British residents are so concerned that their lives on the Costas are threatened, that after many years they're finally learning to speak Spanish.

According to Mijas' Mayor Juan Carlos Maldonado: "When the results of the Brexit (referendum) were known, a big uncertainty was created."

Local traders are also keen to keep the British on the Costa.

Many are retired and spend their pensions here.

Bar owner Sergio Morales says: "Most of our clients here, around 80% of them, are British."

A cloud of uncertainty still hangs over British expats in Spain and elsewhere in Europe.

And it's possible a string of similar nationality schools for expats may spring up.

Not everyone was bemoaning the onset of Brexit.

The art and antique market experienced a mini boom according to London dealers at this winter fair.

The weak pound against the dollar and Euro has seen American collectors in particular start to snap up bargains with savings of beween 25 and 30 per cent compared with six months ago.

Art dealers are reporting a similar trend.

They say investors see the arts market as a safe refuge in uncertain times.

As Christmas approaches the toy industry is bracing itself and Santa is wondering whether he'll have much to be jolly about.

It's the time of year when manufacturers and retailers count on making their biggest cash bonus of the year.

According to industry analyst Frederique Tutt: "Since the Brexit vote the toy market has been faring really well with an increase of three percent."

That's because toy retailers buy stock almost a year in advance and can keep prices stable, but the toy dealers here admit next year the stockings left out for Father Chrismas may have shrunk considerably.

There's nothing as Christmassy as a Christmas tree, but in Denmark the outlook for tree producers isn't quite so evergreen.

According to the Danish Christmas Tree Association, the small Scandinavian country grows around 11.5 million trees a year.

About 9.5 million of those are exported.

But these are challenging times and currency fluctuations are having an effect on trade.

Speaking about his members, Claus Jerram Christensen of the Danish Christmas Tree Association says: "They have experienced that the low exchange rate for the sterling pound makes it more difficult to achieve the same prices."

The true impact of Brexit on Britain and Europe as a whole is still to an extent unknown.

The UK government had announced it was to trigger Article 50 next March to start negotiations to leave EU.

But since then, Brexit has twice been contested in the High Court.

One ruling has already stated Britain's law makers should be allowed a vote in Parliament beforehand.

Breaking up, it seems, really is hard to do.

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LEAD IN:

Scientists controlling EU projects worth millions of dollars say the British exit from Europe risks the future of medical research, and may endanger future treatments for cancer and children.

Research projects at Kings and University Colleges in London rely on the collaboration of hundreds of doctors and multidisciplinary scientists across Europe - which could come under threat because of Brexit.

STORY-LINE:

Precision medicine is changing the future for cancer patients.

This lab at University College London has devised a safer and simpler alternative to standard radioactive techniques of imaging tumours.

Professor Xavier Golay's team has discovered a way to make a tumour light up with a simple sugar solution.

Because the solution is not radioactive is doesn't carry the same side effects which make patients sick.

It means radiodlogists can see tumours in more detail and check them more frequently.

That in turn allows doctors to personalise drug treatments for the patient.

They can respond more quickly, seeing what works and what doesn't and that speed could save more lives.

The team here is about to begin a trial on the new imaging technique thanks to a six and a half million Euro grant from the European Union.

The whole university has 103-million Euros to fund medical and science projects over the next few years.

All currently funded projects will be allowed to complete - but it's what happens next that's vexing doctors and scientist who argue breakthroughs don't come to order at the end of one trial.

Golay says for the vast majority of scientists in Britain the result of the recent EU referendum - for the UK to exit - was a shock.

Golay says it's not just the money which will risk future projects like this.

His team - like most university and hospital research groups - comes from all over the European Union.

Collaboration on this imaging project is with other specialist scientists at the Max Planck Institute in Germany as well as other units including France and Italy.

He's already concerned about the future.

"I've heard of at least two, three very senior people who've said okay right, now I'm taking all my grant with me and I'm going back to Germany, Switzerland, France because actually, in that way, they know they'll still have access and it's not only access to funding because the funding is great in this country, it is really good. It's really (about) access to funding and this opportunity to collaborate."

At preschool age Rens Van Velzen's parents realised he was struggling with dyslexia, but when he went to school it became clear he was autistic.

Van Velzen, now a highly intelligent fifteen year old, is part of Europe's largest study into mental health disorder.

Here researchers like Hannah Haywood combine genetics, neuroimaging, cognitive testing and clinical assessments to try to discover what are the causes.

The research project called EU Aims is carried out here at Kings College London in collaboration with scientists in other centres of Europe.

Costing 32 million Euros it's also the biggest grant given to any one project.

Autism Spectrum Disorder is a developmental problem which affects the way people interact with the world around them.

People are affected differently and scientists want to understand why those differences occur.

Haywood says: "One can go on to a life where they never speak, they are highly affected and quite disabled. Another person can go on (to be) fully verbal and become a professor at Cambridge (University) and someone else can go on and live a full life with marriage and children, why does that happen? Why does it affect people so differently when it's effectively the same condition. So we're trying to answer those questions, we're trying to understand why it affects different people in different ways and I think the thing that really attracted me to the project is because, we're trying to highlight the great skills and strengths in this group as well as the things that people find difficult."

The goal is to identify biomarkers and develop drug treatments.

It's a long term study, but how long can it continue here and what happens to the research after the current funding ends in 2020?

Rens Van Velzen is already preparing for A-levels in maths, chemistry and physics.

But his autism means life outside the classroom is not always straightforward.

He explains: "Quite often when talking peer to peer, the other person can get frustrated with how I respond because they're (I'm) not responding the way that they're expecting me to respond as the people usually do. So quite often I don't pick up someone's annoyed, or that sort of thing. It's very hard to explain because I haven't had the experience of not having autism."

Haywood, like others on the team, is convinced the project must be protected and fears Britain leaving the EU will end large scale endeavours like this which progress more steadily because of the wide collaboration among doctors and scientists.

She says: "Quite often there can be a lot of negativity around being diagnosed and living with the condition and in my work, I've worked with autism for twelve years, I have met some of the most skilled and highly intelligent people."

Van Velzen has been part of the study since it started.

Now he's hoping for a career in astrophysics.

"I think I'll work on either discovering more about our universe and our place in it, or working on ways to get to other parts of the universe," says Van Velzen.

After completing puzzles in record time he goes on for tests in the eye tracking unit.

Studies have used eye-tracing technology to see how long autistic children spend looking at the social and non-social features in a series of images on pictures and videos like these.

Ren's mother Jose Van Velzen is a cognitive neuroscientist herself although she does not work on this project.

While she is confident about her son's academic success she worries about how he will cope with work and whether he will find happiness in personal relationships.

She says: "It is sometimes challenging for Rens to keep track of what the person he's talking to is feeling and how he's being perceived. He's very much driven by telling things as they are, or how he sees them and of course in normal interaction, in normal relationships you constantly monitor what the other person is thinking. That's definitely very challenging for him and he is aware that this is one of his weaknesses he needs to work on he cannot always deal with it at that particular time and I think that is something in general that will make relationships and work environments quite a challenging place for him."

According to scientists here this project is the first of it kind in the world developing the infrastructure which will underpin new treatments for autism.

There are hundreds of scientists involved in British research projects which are funded by the EU.

The lead scientist on the autism project at Kings is Professor Declan Murphy - and he too is concerned about what Brexit will mean.

He says:"It's virtually impossible for one country alone to recruit the amount of patients that you really need for a large scale, modern day trial, or study that's going to lead to reliable results. We increasingly recognise that big questions need big populations to come up with the right answers and we simply cannot deliver the amount of patients for the amount of science from one centre from one country. For Example my work needs approximately a thousand individuals who are affected by autism. You couldn't recruit that from one centre, or from one country within a time frame that is meaningful, but we can do that by going to mulitple centres across Europe, working together and learning from eachother."

The EU's Horizon 2020 budget is 80-billion Euro which funds medicine and science research across Europe.

Britain's split from the EU will leave a funding gap as well as a brain drain according to Murphy and he argues it will be the children with autism who will lose out.

FOR CLEAN VERSION SEE STORY NUMBER: 4045006

LEAD IN:

Scientists controlling EU projects worth millions of dollars say the British exit from Europe risks the future of medical research, and may endanger future treatments for cancer and children.

Research projects at Kings and University Colleges in London rely on the collaboration of hundreds of doctors and multidisciplinary scientists across Europe - which could come under threat because of Brexit.

STORY-LINE:

Precision medicine is changing the future for cancer patients.

This lab at University College London has devised a safer and simpler alternative to standard radioactive techniques of imaging tumours.

Professor Xavier Golay's team has discovered a way to make a tumour light up with a simple sugar solution.

Because the solution is not radioactive is doesn't carry the same side effects which make patients sick.

It means radiodlogists can see tumours in more detail and check them more frequently.

That in turn allows doctors to personalise drug treatments for the patient.

They can respond more quickly, seeing what works and what doesn't and that speed could save more lives.

The team here is about to begin a trial on the new imaging technique thanks to a six and a half million Euro grant from the European Union.

The whole university has 103-million Euros to fund medical and science projects over the next few years.

All currently funded projects will be allowed to complete - but it's what happens next that's vexing doctors and scientist who argue breakthroughs don't come to order at the end of one trial.

Golay says for the vast majority of scientists in Britain the result of the recent EU referendum - for the UK to exit - was a shock.

Golay says it's not just the money which will risk future projects like this.

His team - like most university and hospital research groups - comes from all over the European Union.

Collaboration on this imaging project is with other specialist scientists at the Max Planck Institute in Germany as well as other units including France and Italy.

He's already concerned about the future.

"I've heard of at least two, three very senior people who've said okay right, now I'm taking all my grant with me and I'm going back to Germany, Switzerland, France because actually, in that way, they know they'll still have access and it's not only access to funding because the funding is great in this country, it is really good. It's really (about) access to funding and this opportunity to collaborate."

At preschool age Rens Van Velzen's parents realised he was struggling with dyslexia, but when he went to school it became clear he was autistic.

Van Velzen, now a highly intelligent fifteen year old, is part of Europe's largest study into mental health disorder.

Here researchers like Hannah Haywood combine genetics, neuroimaging, cognitive testing and clinical assessments to try to discover what are the causes.

The research project called EU Aims is carried out here at Kings College London in collaboration with scientists in other centres of Europe.

Costing 32 million Euros it's also the biggest grant given to any one project.

Autism Spectrum Disorder is a developmental problem which affects the way people interact with the world around them.

People are affected differently and scientists want to understand why those differences occur.

Haywood says: "One can go on to a life where they never speak, they are highly affected and quite disabled. Another person can go on (to be) fully verbal and become a professor at Cambridge (University) and someone else can go on and live a full life with marriage and children, why does that happen? Why does it affect people so differently when it's effectively the same condition. So we're trying to answer those questions, we're trying to understand why it affects different people in different ways and I think the thing that really attracted me to the project is because, we're trying to highlight the great skills and strengths in this group as well as the things that people find difficult."

The goal is to identify biomarkers and develop drug treatments.

It's a long term study, but how long can it continue here and what happens to the research after the current funding ends in 2020?

Rens Van Velzen is already preparing for A-levels in maths, chemistry and physics.

But his autism means life outside the classroom is not always straightforward.

He explains: "Quite often when talking peer to peer, the other person can get frustrated with how I respond because they're (I'm) not responding the way that they're expecting me to respond as the people usually do. So quite often I don't pick up someone's annoyed, or that sort of thing. It's very hard to explain because I haven't had the experience of not having autism."

Haywood, like others on the team, is convinced the project must be protected and fears Britain leaving the EU will end large scale endeavours like this which progress more steadily because of the wide collaboration among doctors and scientists.

She says: "Quite often there can be a lot of negativity around being diagnosed and living with the condition and in my work, I've worked with autism for twelve years, I have met some of the most skilled and highly intelligent people."

Van Velzen has been part of the study since it started.

Now he's hoping for a career in astrophysics.

"I think I'll work on either discovering more about our universe and our place in it, or working on ways to get to other parts of the universe," says Van Velzen.

After completing puzzles in record time he goes on for tests in the eye tracking unit.

Studies have used eye-tracing technology to see how long autistic children spend looking at the social and non-social features in a series of images on pictures and videos like these.

Ren's mother Jose Van Velzen is a cognitive neuroscientist herself although she does not work on this project.

While she is confident about her son's academic success she worries about how he will cope with work and whether he will find happiness in personal relationships.

She says: "It is sometimes challenging for Rens to keep track of what the person he's talking to is feeling and how he's being perceived. He's very much driven by telling things as they are, or how he sees them and of course in normal interaction, in normal relationships you constantly monitor what the other person is thinking. That's definitely very challenging for him and he is aware that this is one of his weaknesses he needs to work on he cannot always deal with it at that particular time and I think that is something in general that will make relationships and work environments quite a challenging place for him."

According to scientists here this project is the first of it kind in the world developing the infrastructure which will underpin new treatments for autism.

There are hundreds of scientists involved in British research projects which are funded by the EU.

The lead scientist on the autism project at Kings is Professor Declan Murphy - and he too is concerned about what Brexit will mean.

He says:"It's virtually impossible for one country alone to recruit the amount of patients that you really need for a large scale, modern day trial, or study that's going to lead to reliable results. We increasingly recognise that big questions need big populations to come up with the right answers and we simply cannot deliver the amount of patients for the amount of science from one centre from one country. For Example my work needs approximately a thousand individuals who are affected by autism. You couldn't recruit that from one centre, or from one country within a time frame that is meaningful, but we can do that by going to mulitple centres across Europe, working together and learning from eachother."

The EU's Horizon 2020 budget is 80-billion Euro which funds medicine and science research across Europe.

Britain's split from the EU will leave a funding gap as well as a brain drain according to Murphy and he argues it will be the children with autism who will lose out.

London, UK - 7 July 2016

1. Various CT scans showing liver cancer pre and post therapy to illustrate the relationship between tumours and glucose

2. Mid of Professor Xavier Golay looking at scans in his MRI lab at the UCL Institute of Neurology

3. Various of Golay and researcher looking at scans

4. Close of tumour in rat highlighted by non radioactive glucose

5. SOUNDBITE: (English) Xavier Golay, professor of neurophysics, UCL Institute of Neurology

"I've heard of at least two, three very senior people who've said okay right, now I'm taking all my grant with me and I'm going back to Germany, Switzerland, France because actually, in that way, they know they'll still have access and it's not only access to funding because the funding is great in this country, it is really good. It's really (about) access to funding and this opportunity to collaborate."

6. Close of autistic teenager Rens Van Velzen answering questions testing his cognitive and executive function at Kings College London

7. Close of psychologist Hannah Hayward asking questions

8. Mid of Velzen ticking off words he understands

9. Various of Velzen watching next task being set up

10. Mid of Velzen touching laptop screen to pick out the emotion displayed on the photo on the monitor

11. Close of Velzen touching the word "Cautious"

12. Close of touch screen

13. Mid of Velzen watching screen observed by Hayward

14. Close of Velzen

15. SOUNDBITE: (English) Hannah Hayward psychologist, EU Aims (autism research project) Kings College London

"One can go on to a life where they never speak, they are highly affected and quite disabled. Another person can go on (to be) fully verbal and become a professor at Cambridge (University) and someone else can go on and live a full life with marriage and children, why does that happen? Why does it affect people so differently when it's effectively the same condition? So we're trying to answer those questions, we're trying to understand why it affects different people in different ways and I think the thing that really attracted me to the project is because, we're trying to highlight the great skills and strengths in this group as well as the things that people find difficult."

16. Close of Hayward starting stopwatch

17. Close of cube pattern Velzen has to recreate

18. Close tilt down of Hayward observing

19. Close of Velzen

20. Close pan from pattern and blocks being constructed by Velzen

21. Mid of Velzen completing puzzle watched by Hayward

22. SOUNDBITE: (English) Rens Van Velzen, teenager in Kings College autisim research group

"Quite often when talking peer to peer, the other person can get frustrated with how I respond because they're (I'm) not responding the way that they're expecting me to respond as the people usually do. So quite often I don't pick up someone's annoyed, or that sort of thing. It's very hard to explain because I haven't had the experience of not having autism."

23. Various of Van Velzen completing other puzzles with black and yellow blocks

24. SOUNDBITE: (English) Hannah Hayward psychologist, EU Aims (autism research project) Kings College London

"Quite often there can be a lot of negativity around being diagnosed and living with the condition and in my work, I've worked with autism for twelve years, I have met some of the most skilled and highly intelligent people."

25. Various of Hayward attaching EEG wires to Van Velzen before eye tracking tests

26. SOUNDBITE: (English) Rens Van Velzen, teenager in Kings College autisim research group

"I think I'll work on either discovering more about our universe and our place in it, or working on ways to get to other parts of the universe."

27. Mid of monitor displaying photographs of facial expressions with options to pick the right description

28. Close of Van Velsen tapping keyboard

29. Mid of test continuing on monitor

30. SOUNDBITE: (English) Jose Van Velzen, Rens' mother (who is also a cognitive neuroscientist)

"It is sometimes challenging for Rens to keep track of what the person he's talking to is feeling and how he's being perceived. He's very much driven by telling things as they are, or how he sees them and of course in normal interaction, in normal relationships, you constantly monitor what the other person is thinking. That's definitely very challenging for him, and he is aware that this is one of his weaknesses he needs to work on he cannot always deal with it at that particular time and I think that is something in general that will make relationships and work environments quite a challenging place for him."

31. Mid rear view of Rens Van Velzen being shown photos in the eye tracking suite

32. Various of monitor

33. Various of Hayward carrying out tracking test

34. Hayward's monitor showing Rens Van Velzen responding to photographs

35. Mid rear view of Van Velzen watching animated patterns appear on screen

36. Various of Professor Declan Murphy lead scientist on the EU Aims study on autism

37. SOUNDBITE: (English) Professor Declan Murphy lead scientist, EU Aims study on autism, Kings College London

"It's virtually impossible for one country alone to recruit the amount of patients that you really need for a large scale, modern day trial, or study that's going to lead to reliable results. We increasingly recognise that big questions need big populations to come up with the right answers, and we simply cannot deliver the amount of patients for the amount of science from one centre from one country. For example, my work needs approximately a thousand individuals who are affected by autism. You couldn't recruit that from one centre, or from one country within a time frame that is meaningful, but we can do that by going to mulitple centres across Europe, working together and learning from eachother."

38. Mid rear view of Rens Van Velzen responding to picture during eyetracking test

39. Close of EEG reading on monitor

UK MEDICAL BREXIT

SOURCE: AP HORIZONS, LIFESTYLE, HEALTH AND TECHNOLOGY

RESTRICTIONS: HORIZONS CLIENTS AND AP LIFESTYLE, HEALTH AND TECHNOLOGY CLIENTS ONLY

LENGTH: 6.33

SHOTLIST:

London, UK - 7 July 2016

1. Various CT scans showing liver cancer pre and post therapy to illustrate the relationship between tumours and glucose

2. Mid of Professor Xavier Golay looking at scans in his MRI lab at the UCL Institute of Neurology

3. Various of Golay and researcher looking at scans

4. Close of tumour in rat highlighted by non radioactive glucose

5. SOUNDBITE: (English) Xavier Golay, professor of neurophysics, UCL Institute of Neurology

"I've heard of at least two, three very senior people who've said okay right, now I'm taking all my grant with me and I'm going back to Germany, Switzerland, France because actually, in that way, they know they'll still have access and it's not only access to funding because the funding is great in this country, it is really good. It's really (about) access to funding and this opportunity to collaborate."

6. Close of autistic teenager Rens Van Velzen answering questions testing his cognitive and executive function at Kings College London

7. Close of psychologist Hannah Hayward asking questions

8. Mid of Velzen ticking off words he understands

9. Various of Velzen watching next task being set up

10. Mid of Velzen touching laptop screen to pick out the emotion displayed on the photo on the monitor

11. Close of Velzen touching the word "Cautious"

12. Close of touch screen

13. Mid of Velzen watching screen observed by Hayward

14. Close of Velzen

15. SOUNDBITE: (English) Hannah Hayward psychologist, EU Aims (autism research project) Kings College London

"One can go on to a life where they never speak, they are highly affected and quite disabled. Another person can go on (to be) fully verbal and become a professor at Cambridge (University) and someone else can go on and live a full life with marriage and children, why does that happen? Why does it affect people so differently when it's effectively the same condition? So we're trying to answer those questions, we're trying to understand why it affects different people in different ways and I think the thing that really attracted me to the project is because, we're trying to highlight the great skills and strengths in this group as well as the things that people find difficult."

16. Close of Hayward starting stopwatch

17. Close of cube pattern Velzen has to recreate

18. Close tilt down of Hayward observing

19. Close of Velzen

20. Close pan from pattern and blocks being constructed by Velzen

21. Mid of Velzen completing puzzle watched by Hayward

22. SOUNDBITE: (English) Rens Van Velzen, teenager in Kings College autisim research group

"Quite often when talking peer to peer, the other person can get frustrated with how I respond because they're (I'm) not responding the way that they're expecting me to respond as the people usually do. So quite often I don't pick up someone's annoyed, or that sort of thing. It's very hard to explain because I haven't had the experience of not having autism."

23. Various of Van Velzen completing other puzzles with black and yellow blocks

24. SOUNDBITE: (English) Hannah Hayward psychologist, EU Aims (autism research project) Kings College London

"Quite often there can be a lot of negativity around being diagnosed and living with the condition and in my work, I've worked with autism for twelve years, I have met some of the most skilled and highly intelligent people."

25. Various of Hayward attaching EEG wires to Van Velzen before eye tracking tests

26. SOUNDBITE: (English) Rens Van Velzen, teenager in Kings College autisim research group

"I think I'll work on either discovering more about our universe and our place in it, or working on ways to get to other parts of the universe."

27. Mid of monitor displaying photographs of facial expressions with options to pick the right description

28. Close of Van Velsen tapping keyboard

29. Mid of test continuing on monitor

30. SOUNDBITE: (English) Jose Van Velzen, Rens' mother (who is also a cognitive neuroscientist)

"It is sometimes challenging for Rens to keep track of what the person he's talking to is feeling and how he's being perceived. He's very much driven by telling things as they are, or how he sees them and of course in normal interaction, in normal relationships, you constantly monitor what the other person is thinking. That's definitely very challenging for him, and he is aware that this is one of his weaknesses he needs to work on he cannot always deal with it at that particular time and I think that is something in general that will make relationships and work environments quite a challenging place for him."

31. Mid rear view of Rens Van Velzen being shown photos in the eye tracking suite

32. Various of monitor

33. Various of Hayward carrying out tracking test

34. Hayward's monitor showing Rens Van Velzen responding to photographs

35. Mid rear view of Van Velzen watching animated patterns appear on screen

36. Various of Professor Declan Murphy lead scientist on the EU Aims study on autism

37. SOUNDBITE: (English) Professor Declan Murphy lead scientist, EU Aims study on autism, Kings College London

"It's virtually impossible for one country alone to recruit the amount of patients that you really need for a large scale, modern day trial, or study that's going to lead to reliable results. We increasingly recognise that big questions need big populations to come up with the right answers, and we simply cannot deliver the amount of patients for the amount of science from one centre from one country. For example, my work needs approximately a thousand individuals who are affected by autism. You couldn't recruit that from one centre, or from one country within a time frame that is meaningful, but we can do that by going to mulitple centres across Europe, working together and learning from eachother."

38. Mid rear view of Rens Van Velzen responding to picture during eyetracking test

39. Close of EEG reading on monitor

LEADIN:

Scientists controlling EU projects worth millions of dollars say the British exit from Europe risks the future of medical research, and may endanger future treatments for cancer and children.

Research projects at Kings and University Colleges in London rely on the collaboration of hundreds of doctors and multidisciplinary scientists across Europe - which could come under threat because of Brexit.

STORYLINE:

Precision medicine is changing the future for cancer patients.

This lab at University College London has devised a safer and simpler alternative to standard radioactive techniques of imaging tumours.

Professor Xavier Golay's team has discovered a way to make a tumour light up with a simple sugar solution.

Because the solution is not radioactive is doesn't carry the same side effects which make patients sick.

It means radiodlogists can see tumours in more detail and check them more frequently.

That in turn allows doctors to personalise drug treatments for the patient.

They can respond more quickly, seeing what works and what doesn't and that speed could save more lives.

The team here is about to begin a trial on the new imaging technique thanks to a six and a half million Euro grant from the European Union.

The whole university has 103-million Euros to fund medical and science projects over the next few years.

All currently funded projects will be allowed to complete - but it's what happens next that's vexing doctors and scientist who argue breakthroughs don't come to order at the end of one trial.

Golay says for the vast majority of scientists in Britain the result of the recent EU referendum - for the UK to exit - was a shock.

Golay says it's not just the money which will risk future projects like this.

His team - like most university and hospital research groups - comes from all over the European Union.

Collaboration on this imaging project is with other specialist scientists at the Max Planck Institute in Germany as well as other units including France and Italy.

He's already concerned about the future.

"I've heard of at least two, three very senior people who've said okay right, now I'm taking all my grant with me and I'm going back to Germany, Switzerland, France because actually, in that way, they know they'll still have access and it's not only access to funding because the funding is great in this country, it is really good. It's really (about) access to funding and this opportunity to collaborate."

At preschool age Rens Van Velzen's parents realised he was struggling with dyslexia, but when he went to school it became clear he was autistic.

Van Velzen, now a highly intelligent fifteen year old, is part of Europe's largest study into mental health disorder.

Here researchers like Hannah Haywood combine genetics, neuroimaging, cognitive testing and clinical assessments to try to discover what are the causes.

The research project called EU Aims is carried out here at Kings College London in collaboration with scientists in other centres of Europe.

Costing 32 million Euros it's also the biggest grant given to any one project.

Autism Spectrum Disorder is a developmental problem which affects the way people interact with the world around them.

People are affected differently and scientists want to understand why those differences occur.

Haywood says: "One can go on to a life where they never speak, they are highly affected and quite disabled. Another person can go on (to be) fully verbal and become a professor at Cambridge (University) and someone else can go on and live a full life with marriage and children, why does that happen? Why does it affect people so differently when it's effectively the same condition. So we're trying to answer those questions, we're trying to understand why it affects different people in different ways and I think the thing that really attracted me to the project is because, we're trying to highlight the great skills and strengths in this group as well as the things that people find difficult."

The goal is to identify biomarkers and develop drug treatments.

It's a long term study, but how long can it continue here and what happens to the research after the current funding ends in 2020?

Rens Van Velzen is already preparing for A-levels in maths, chemistry and physics.

But his autism means life outside the classroom is not always straightforward.

He explains: "Quite often when talking peer to peer, the other person can get frustrated with how I respond because they're (I'm) not responding the way that they're expecting me to respond as the people usually do. So quite often I don't pick up someone's annoyed, or that sort of thing. It's very hard to explain because I haven't had the experience of not having autism."

Haywood, like others on the team, is convinced the project must be protected and fears Britain leaving the EU will end large scale endeavours like this which progress more steadily because of the wide collaboration among doctors and scientists.

She says: "Quite often there can be a lot of negativity around being diagnosed and living with the condition and in my work, I've worked with autism for twelve years, I have met some of the most skilled and highly intelligent people."

Van Velzen has been part of the study since it started.

Now he's hoping for a career in astrophysics.

"I think I'll work on either discovering more about our universe and our place in it, or working on ways to get to other parts of the universe," says Van Velzen.

After completing puzzles in record time he goes on for tests in the eye tracking unit.

Studies have used eye-tracing technology to see how long autistic children spend looking at the social and non-social features in a series of images on pictures and videos like these.

Ren's mother Jose Van Velzen is a cognitive neuroscientist herself although she does not work on this project.

While she is confident about her son's academic success she worries about how he will cope with work and whether he will find happiness in personal relationships.

She says: "It is sometimes challenging for Rens to keep track of what the person he's talking to is feeling and how he's being perceived. He's very much driven by telling things as they are, or how he sees them and of course in normal interaction, in normal relationships you constantly monitor what the other person is thinking. That's definitely very challenging for him and he is aware that this is one of his weaknesses he needs to work on he cannot always deal with it at that particular time and I think that is something in general that will make relationships and work environments quite a challenging place for him."

According to scientists here this project is the first of it kind in the world developing the infrastructure which will underpin new treatments for autism.

There are hundreds of scientists involved in British research projects which are funded by the EU.

The lead scientist on the autism project at Kings is Professor Declan Murphy - and he too is concerned about what Brexit will mean.

He says:"It's virtually impossible for one country alone to recruit the amount of patients that you really need for a large scale, modern day trial, or study that's going to lead to reliable results. We increasingly recognise that big questions need big populations to come up with the right answers and we simply cannot deliver the amount of patients for the amount of science from one centre from one country. For Example my work needs approximately a thousand individuals who are affected by autism. You couldn't recruit that from one centre, or from one country within a time frame that is meaningful, but we can do that by going to mulitple centres across Europe, working together and learning from each other."

The EU's Horizon 2020 budget is 80-billion Euro which funds medicine and science research across Europe.

Britain's split from the EU will leave a funding gap as well as a brain drain according to Murphy and he argues it will be the children with autism who will lose out.

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UK MEDICAL BREXIT

SOURCE: AP TECHNOLOGY

RESTRICTIONS: TECHNOLOGY CLIENTS ONLY

LENGTH: 6.33

SHOTLIST:

London, UK - 7 July 2016

1. Various CT scans showing liver cancer pre and post therapy to illustrate the relationship between tumours and glucose

2. Mid of Professor Xavier Golay looking at scans in his MRI lab at the UCL Institute of Neurology

3. Various of Golay and researcher looking at scans

4. Close of tumour in rat highlighted by non radioactive glucose

5. SOUNDBITE: (English) Xavier Golay, professor of neurophysics, UCL Institute of Neurology

"I've heard of at least two, three very senior people who've said okay right, now I'm taking all my grant with me and I'm going back to Germany, Switzerland, France because actually, in that way, they know they'll still have access and it's not only access to funding because the funding is great in this country, it is really good. It's really (about) access to funding and this opportunity to collaborate."

6. Close of autistic teenager Rens Van Velzen answering questions testing his cognitive and executive function at Kings College London

7. Close of psychologist Hannah Hayward asking questions

8. Mid of Velzen ticking off words he understands

9. Various of Velzen watching next task being set up

10. Mid of Velzen touching laptop screen to pick out the emotion displayed on the photo on the monitor

11. Close of Velzen touching the word "Cautious"

12. Close of touch screen

13. Mid of Velzen watching screen observed by Hayward

14. Close of Velzen

15. SOUNDBITE: (English) Hannah Hayward psychologist, EU Aims (autism research project) Kings College London

"One can go on to a life where they never speak, they are highly affected and quite disabled. Another person can go on (to be) fully verbal and become a professor at Cambridge (University) and someone else can go on and live a full life with marriage and children, why does that happen? Why does it affect people so differently when it's effectively the same condition? So we're trying to answer those questions, we're trying to understand why it affects different people in different ways and I think the thing that really attracted me to the project is because, we're trying to highlight the great skills and strengths in this group as well as the things that people find difficult."

16. Close of Hayward starting stopwatch

17. Close of cube pattern Velzen has to recreate

18. Close tilt down of Hayward observing

19. Close of Velzen

20. Close pan from pattern and blocks being constructed by Velzen

21. Mid of Velzen completing puzzle watched by Hayward

22. SOUNDBITE: (English) Rens Van Velzen, teenager in Kings College autisim research group

"Quite often when talking peer to peer, the other person can get frustrated with how I respond because they're (I'm) not responding the way that they're expecting me to respond as the people usually do. So quite often I don't pick up someone's annoyed, or that sort of thing. It's very hard to explain because I haven't had the experience of not having autism."

23. Various of Van Velzen completing other puzzles with black and yellow blocks

24. SOUNDBITE: (English) Hannah Hayward psychologist, EU Aims (autism research project) Kings College London

"Quite often there can be a lot of negativity around being diagnosed and living with the condition and in my work, I've worked with autism for twelve years, I have met some of the most skilled and highly intelligent people."

25. Various of Hayward attaching EEG wires to Van Velzen before eye tracking tests

26. SOUNDBITE: (English) Rens Van Velzen, teenager in Kings College autisim research group

"I think I'll work on either discovering more about our universe and our place in it, or working on ways to get to other parts of the universe."

27. Mid of monitor displaying photographs of facial expressions with options to pick the right description

28. Close of Van Velsen tapping keyboard

29. Mid of test continuing on monitor

30. SOUNDBITE: (English) Jose Van Velzen, Rens' mother (who is also a cognitive neuroscientist)

"It is sometimes challenging for Rens to keep track of what the person he's talking to is feeling and how he's being perceived. He's very much driven by telling things as they are, or how he sees them and of course in normal interaction, in normal relationships, you constantly monitor what the other person is thinking. That's definitely very challenging for him, and he is aware that this is one of his weaknesses he needs to work on he cannot always deal with it at that particular time and I think that is something in general that will make relationships and work environments quite a challenging place for him."

31. Mid rear view of Rens Van Velzen being shown photos in the eye tracking suite

32. Various of monitor

33. Various of Hayward carrying out tracking test

34. Hayward's monitor showing Rens Van Velzen responding to photographs

35. Mid rear view of Van Velzen watching animated patterns appear on screen

36. Various of Professor Declan Murphy lead scientist on the EU Aims study on autism

37. SOUNDBITE: (English) Professor Declan Murphy lead scientist, EU Aims study on autism, Kings College London

"It's virtually impossible for one country alone to recruit the amount of patients that you really need for a large scale, modern day trial, or study that's going to lead to reliable results. We increasingly recognise that big questions need big populations to come up with the right answers, and we simply cannot deliver the amount of patients for the amount of science from one centre from one country. For example, my work needs approximately a thousand individuals who are affected by autism. You couldn't recruit that from one centre, or from one country within a time frame that is meaningful, but we can do that by going to mulitple centres across Europe, working together and learning from eachother."

38. Mid rear view of Rens Van Velzen responding to picture during eyetracking test

39. Close of EEG reading on monitor

LEADIN:

Scientists controlling EU projects worth millions of dollars say the British exit from Europe risks the future of medical research, and may endanger future treatments for cancer and children.

Research projects at Kings and University Colleges in London rely on the collaboration of hundreds of doctors and multidisciplinary scientists across Europe - which could come under threat because of Brexit.

STORYLINE:

Precision medicine is changing the future for cancer patients.

This lab at University College London has devised a safer and simpler alternative to standard radioactive techniques of imaging tumours.

Professor Xavier Golay's team has discovered a way to make a tumour light up with a simple sugar solution.

Because the solution is not radioactive is doesn't carry the same side effects which make patients sick.

It means radiodlogists can see tumours in more detail and check them more frequently.

That in turn allows doctors to personalise drug treatments for the patient.

They can respond more quickly, seeing what works and what doesn't and that speed could save more lives.

The team here is about to begin a trial on the new imaging technique thanks to a six and a half million Euro grant from the European Union.

The whole university has 103-million Euros to fund medical and science projects over the next few years.

All currently funded projects will be allowed to complete - but it's what happens next that's vexing doctors and scientist who argue breakthroughs don't come to order at the end of one trial.

Golay says for the vast majority of scientists in Britain the result of the recent EU referendum - for the UK to exit - was a shock.

Golay says it's not just the money which will risk future projects like this.

His team - like most university and hospital research groups - comes from all over the European Union.

Collaboration on this imaging project is with other specialist scientists at the Max Planck Institute in Germany as well as other units including France and Italy.

He's already concerned about the future.

"I've heard of at least two, three very senior people who've said okay right, now I'm taking all my grant with me and I'm going back to Germany, Switzerland, France because actually, in that way, they know they'll still have access and it's not only access to funding because the funding is great in this country, it is really good. It's really (about) access to funding and this opportunity to collaborate."

At preschool age Rens Van Velzen's parents realised he was struggling with dyslexia, but when he went to school it became clear he was autistic.

Van Velzen, now a highly intelligent fifteen year old, is part of Europe's largest study into mental health disorder.

Here researchers like Hannah Haywood combine genetics, neuroimaging, cognitive testing and clinical assessments to try to discover what are the causes.

The research project called EU Aims is carried out here at Kings College London in collaboration with scientists in other centres of Europe.

Costing 32 million Euros it's also the biggest grant given to any one project.

Autism Spectrum Disorder is a developmental problem which affects the way people interact with the world around them.

People are affected differently and scientists want to understand why those differences occur.

Haywood says: "One can go on to a life where they never speak, they are highly affected and quite disabled. Another person can go on (to be) fully verbal and become a professor at Cambridge (University) and someone else can go on and live a full life with marriage and children, why does that happen? Why does it affect people so differently when it's effectively the same condition. So we're trying to answer those questions, we're trying to understand why it affects different people in different ways and I think the thing that really attracted me to the project is because, we're trying to highlight the great skills and strengths in this group as well as the things that people find difficult."

The goal is to identify biomarkers and develop drug treatments.

It's a long term study, but how long can it continue here and what happens to the research after the current funding ends in 2020?

Rens Van Velzen is already preparing for A-levels in maths, chemistry and physics.

But his autism means life outside the classroom is not always straightforward.

He explains: "Quite often when talking peer to peer, the other person can get frustrated with how I respond because they're (I'm) not responding the way that they're expecting me to respond as the people usually do. So quite often I don't pick up someone's annoyed, or that sort of thing. It's very hard to explain because I haven't had the experience of not having autism."

Haywood, like others on the team, is convinced the project must be protected and fears Britain leaving the EU will end large scale endeavours like this which progress more steadily because of the wide collaboration among doctors and scientists.

She says: "Quite often there can be a lot of negativity around being diagnosed and living with the condition and in my work, I've worked with autism for twelve years, I have met some of the most skilled and highly intelligent people."

Van Velzen has been part of the study since it started.

Now he's hoping for a career in astrophysics.

"I think I'll work on either discovering more about our universe and our place in it, or working on ways to get to other parts of the universe," says Van Velzen.

After completing puzzles in record time he goes on for tests in the eye tracking unit.

Studies have used eye-tracing technology to see how long autistic children spend looking at the social and non-social features in a series of images on pictures and videos like these.

Ren's mother Jose Van Velzen is a cognitive neuroscientist herself although she does not work on this project.

While she is confident about her son's academic success she worries about how he will cope with work and whether he will find happiness in personal relationships.

She says: "It is sometimes challenging for Rens to keep track of what the person he's talking to is feeling and how he's being perceived. He's very much driven by telling things as they are, or how he sees them and of course in normal interaction, in normal relationships you constantly monitor what the other person is thinking. That's definitely very challenging for him and he is aware that this is one of his weaknesses he needs to work on he cannot always deal with it at that particular time and I think that is something in general that will make relationships and work environments quite a challenging place for him."

According to scientists here this project is the first of it kind in the world developing the infrastructure which will underpin new treatments for autism.

There are hundreds of scientists involved in British research projects which are funded by the EU.

The lead scientist on the autism project at Kings is Professor Declan Murphy - and he too is concerned about what Brexit will mean.

He says:"It's virtually impossible for one country alone to recruit the amount of patients that you really need for a large scale, modern day trial, or study that's going to lead to reliable results. We increasingly recognise that big questions need big populations to come up with the right answers and we simply cannot deliver the amount of patients for the amount of science from one centre from one country. For Example my work needs approximately a thousand individuals who are affected by autism. You couldn't recruit that from one centre, or from one country within a time frame that is meaningful, but we can do that by going to mulitple centres across Europe, working together and learning from each other."

The EU's Horizon 2020 budget is 80-billion Euro which funds medicine and science research across Europe.

Britain's split from the EU will leave a funding gap as well as a brain drain according to Murphy and he argues it will be the children with autism who will lose out.

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